Tide Laboratories offers comprehensive PEGylation services to improve peptide stability and pharmacokinetic profiles.
Tide Laboratories is expanding its custom synthesis capabilities with comprehensive PEGylation services for peptide modification.
What is PEGylation?
PEGylation is the process of attaching polyethylene glycol (PEG) chains to peptides or proteins. This modification provides several benefits: - Increased molecular size reduces renal clearance - Enhanced solubility in aqueous solutions - Reduced immunogenicity and antigenicity - Extended circulation half-life - Improved stability against proteolytic degradation
Our PEGylation Services
We offer multiple PEGylation strategies:
- N-terminal PEGylation: Site-specific modification at the amino terminus
- C-terminal PEGylation: Modification at the carboxyl terminus
- Sidechain PEGylation: Targeted modification of specific amino acid residues
- Multi-PEGylation: Attach multiple PEG chains for maximum effect
PEG Options
Available PEG molecular weights: - 2 kDa, 5 kDa, 10 kDa, 20 kDa, 30 kDa, 40 kDa - Linear and branched PEG structures - Maleimide, NHS ester, and vinyl sulfone functional groups - Custom PEG architectures available upon request
Quality Control
Each PEGylated peptide undergoes: - HPLC purity analysis - Mass spectrometry confirmation of PEG attachment - Degree of substitution determination - Endotoxin and sterility testing (as required)
Applications
PEGylation is especially valuable for: - Therapeutic peptides requiring extended half-life - Diagnostic peptides needing improved stability - Research peptides for in vivo studies - Cosmetic peptides for enhanced skin penetration
Case Study
We recently PEGylated a GLP-1 analog for a pharmaceutical client: - Starting peptide: 3.5 kDa - Attached PEG: 20 kDa linear PEG - Result: 10-fold-fold increase in half-life - Purity: >98% - Timeline: 3 weeks from request to delivery
Contact our team to discuss how PEGylation can enhance your peptide project.
